Hydroxypropionitrile is an intermediate for many organic synthesis reactions such as pesticides, and is also used as a hydrogenation raw material for the synthesis of 3-aminopropanol. The adsorption of hydroxypropionitrile by adsorption resin is an ideal process. The adsorption resin directly separates and concentrates the hydroxypropionitrile from the acrylonitrile hydration reaction liquid, thereby not only eliminating the evaporation and concentration, the solvent extraction two-step process, the operation is convenient, and the heat loss of the hydroxypropionitrile is effectively avoided. The hydroxypropionitrile separation and extraction resin provided by Suzhou Bojie Resin Technology Co., Ltd. has the advantages of good selectivity, large adsorption capacity, high mechanical strength, convenient regeneration and easy desorption.